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The best medicine for ADHD Inattentive (ADHD-PI) or Inattentive ADD is most likely not Ritalin. You can find some psychiatrists that think that Inattentive ADD or ADHD-PI may not be ADHD in any respect and that patients using this subtype of ADHD may respond totally differently than the other subtypes to stimulant medication.

Dr. Russell Barkley, a foremost authority on ADHD, has written this about treating the inattentive subtype of ADHD: Adderall "These children don't respond to stimulants anywhere near as well as AD/HD hyperactive, impulsive children do. Only about one in five of these children can have a sufficiently therapeutic response to keep up them on medication after a primary period of titration. Oh, you'll realize that about two-thirds ones show mild improvement, but those improvements aren't enough to warrant calling them clinical responders, therapeutic responders. Ninety-two percent of AD/HD children respond to stimulants. Twenty percent of those children react to stimulants. And the dosing is different. AD/HD children tend to be better on moderate to high doses. Inattentive children, if they're planning to respond at all, it's at very light doses, small doses. "

Many people who have ADHD-PI however, successfully use stimulant treatment. For many people a good mild improvement is sufficient cause to remain around the medication. The very best medicine is usually tailored to each individual but there exists data that Ritalin works less well for ADHD-PI compared to Adderall family of drugs. It would be nice, I think, to have a fairly easy and quick reference for that medicines used to treat for Primarily Inattentive ADHD. To better understand the treatments available, a really basic lesson within the biology of ADHD is handy.

All types of ADHD are believed to be the result of a trouble with neurotransmitters in our brain. The two neurotransmitters that result in the major symptoms of ADHD are Dopamine and Epinephrine (norepinephrine). Very simply stated, a minimal level of dopamine in your brain can cause hyperactivity and impulsivity. A low quantity of epinephrine can cause insufficient focus, lethargy, and mental fatigue. Serotonin, another neurotransmitter, is secreted and depleted in tandem with dopamine and epinephrine. Low amounts of serotonin make us irritable, tired, and depressed. The degree of circulating serotonin is related to the levels of the other two neurotransmitters and vice versa.

All the control of ADHD try to optimize neurotransmitter function inside the brain. The Ritalin (Methylphenidate) family operates by increasing both brain dopamine and epinephrine. The Adderall (Amphetamine) family operates by increasing brain epinephrine and dopamine but this category of drugs increases dopamine by only about 50 % around Methylphenidate. Strattera (atomoxetine) operates by increasing brain norepinephrine. Guanfacine (Intuniv) regulates the flow and effectiveness of neurotransmitter receptors inside brain in the method in which reduces hyperactivity, improves working memory, and diminishes impulsivity, and distractibility.

So what could be the best medicine for ADHD-PI? Some doctors believe that this Adderall family works better compared to the Ritalin family for that inattentives because the medication's effects on norepinephrine are greater as opposed to effects on dopamine. All stimulants could make some inattentives anxious but ADHD-PI patients seem to tolerate the amphetamines much better than they tolerate the Ritalin family.

It would seem that applying this quite simple understanding with the biology of ADHD, that Strattera should work the best for ADHD-PI. The fact is that Strattera only works for some patients with ADHD-PI. We have been not sure why this really is the case. It would also seem that Intuniv is acceptable poorly for folks with ADHD-PI as its main effect is on hyperactivity. The fact is that some doctors have found out that Intuniv is effective for ADHD-PI patients.

Because some folks with ADHD also provide difficulties with depression and anxiety, antidepressants for example the tricyclics (Elavil, Norpramin, Tofranil) which work on Norepinephrine and Serotonin are sometimes prescribed. There are many patients who report relief with their inattentive symptoms once they are treated with the tricyclics. The SSRIs, the selective serotonin reuptake inhibitors, (Prozac, Paxil, Celexa) work only on serotonin and are sometimes found in conjunction using the stimulants to take care of ADHD-PI with depression but might also help inattention.

All of the medications might have side effects. The stimulants can cause weight loss, anxiety, and sleep issues. Intuniv could cause drops in blood pressure levels and sleepiness, Strattera could cause sexual dysfunction and it has as carry out the SSRIs a warning for pediatric patients regarding an increased probability of agitation, irritability and suicidal thinking. Usually the medication unwanted effects are mild or rare but once they are not, they'll unfortunately dictate what treatment might be used.

Some researchers think that once we now have mapped the genetic issues involved in ADHD, we will be capable to tailor individual treatments for everybody with ADHD. This is a tall order because the neurotransmitter actions within the brain are complex and none in the neurotransmitters work independently. The number of symptoms in ADHD are also interrelated and complex.

Given the person and different symptom manifestation of ADHD, as well as the differences within the occurrence and tolerance of medication side effects, the management of ADHD-PI will invariably be, with a extent, a procedure for individual trial and error.